Abstract
Flavonoids are a large group of ubiquitous molecules synthesized by plants. Recent research has revealed that these molecules possess antioxidant activities which prevent free-radical damage to biological molecules like lipids, proteins and DNA, damage which can cause many cardiovascular and neurodegenerative diseases as well as cancer and diabetes. The underlying mechanisms involve metal chelation, free-radical scavenger capacities and inhibition of freeradical producing enzymes. Structure-activity studies have demonstrated common features of flavonoids that are highly important to their different activities. They include their planar structure; the number and position of their hydroxyl groups as well as the presence of the C2-C3 double bond. Many research groups indicated that flavonoids have shown cardioprotective activity, mainly through inhibition of lipid peroxidation. More recently, flavonoids are proven to be effective as anti-cancer agents, through apoptosis by induction of cell cycle arrest and inhibition of key enzymes involved in tumor promotion. Although discrepancies between in vitro and in vivo studies have been found, the elucidation of the mechanisms involved in flavonoid action will have many health benefits to man.
Keywords: Flavonoids, Antioxidant, Lipid peroxidation, Cardioprotective, Anti-cancer
Current Nutrition & Food Science
Title: Flavonoids in Human Health: From Structure to Biological Activity
Volume: 5 Issue: 4
Author(s): Djebbar Atmani, Nassima Chaher, Dina Atmani, Meriem Berboucha, Nadjet Debbache and Hania Boudaoud
Affiliation:
Keywords: Flavonoids, Antioxidant, Lipid peroxidation, Cardioprotective, Anti-cancer
Abstract: Flavonoids are a large group of ubiquitous molecules synthesized by plants. Recent research has revealed that these molecules possess antioxidant activities which prevent free-radical damage to biological molecules like lipids, proteins and DNA, damage which can cause many cardiovascular and neurodegenerative diseases as well as cancer and diabetes. The underlying mechanisms involve metal chelation, free-radical scavenger capacities and inhibition of freeradical producing enzymes. Structure-activity studies have demonstrated common features of flavonoids that are highly important to their different activities. They include their planar structure; the number and position of their hydroxyl groups as well as the presence of the C2-C3 double bond. Many research groups indicated that flavonoids have shown cardioprotective activity, mainly through inhibition of lipid peroxidation. More recently, flavonoids are proven to be effective as anti-cancer agents, through apoptosis by induction of cell cycle arrest and inhibition of key enzymes involved in tumor promotion. Although discrepancies between in vitro and in vivo studies have been found, the elucidation of the mechanisms involved in flavonoid action will have many health benefits to man.
Export Options
About this article
Cite this article as:
Atmani Djebbar, Chaher Nassima, Atmani Dina, Berboucha Meriem, Debbache Nadjet and Boudaoud Hania, Flavonoids in Human Health: From Structure to Biological Activity, Current Nutrition & Food Science 2009; 5 (4) . https://dx.doi.org/10.2174/157340109790218049
DOI https://dx.doi.org/10.2174/157340109790218049 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
Call for Papers in Thematic Issues
Bioactive compounds, functional foods, metabolism, and health
Nutrition, metabolism, and their intervention strategies have become focal points of interest in the study of metabolic syndrome and health. Bioactive compounds, phytochemicals, and functional foods play crucial roles in modulating metabolic processes and improving human health. Moreover, the composition of the gut microbiome is also believed to be closely ...read more
Functional Foods in Human Health and Beyond
Foods are important source of nutrients including carbohydrates, proteins, lipids and other minerals. Furthermore, the functional foods are those agents that have additional components that are essential supports to the body in terms of antioxidant and pharmacologically active agents. The predominant functional foods are of plant in origin, whereas some ...read more
Harnessing Bioactive Compounds from Food Waste: Sustainable Extraction Strategies and Health Applications
Food waste presents a significant challenge across the postharvest cycle, from agricultural production to distribution. However, within this waste lies a treasure trove of bioactive chemicals that hold immense potential for nutraceuticals, functional foods, and postharvest additives, including antimicrobials. Various extraction methods, such as solvent extraction (SE), supercritical fluid extraction ...read more
Natural Bioactive Compounds Derivatives in Nutraceutical and Food Science
In the last years, plants have been widely used for their numerous properties and now there is growing interest in the study of classes of compounds obtained from plant species or derived from them. The importance of these natural compounds lies in their important therapeutic purposes, and in their capability ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Genomics in Cardiovascular Medicine
Current Genomics Post-stroke Depression Therapy: Where are we now?
Current Neurovascular Research Potential Effect of Anti-Tumour Necrosis Factor-Alpha Treatment on Reducing the Cardiovascular Risk Related to Rheumatoid Arthritis
Current Vascular Pharmacology Metalloproteinases and Metalloproteinase Inhibitors in Age-Related Diseases
Current Pharmaceutical Design The Histamine H3 Receptor as a Therapeutic Drug Target for Metabolic Disorders: Status, Challenges and Opportunities
Current Topics in Medicinal Chemistry Isolated Perioperative Hypertension: Clinical Implications & Contemporary Treatment Strategies
Current Hypertension Reviews Editorial: Modifying Cardiovascular Risk Factors: Acquired Topics and Emerging Concepts
Current Pharmaceutical Design Understanding and Avoiding Antiretroviral Adverse Events
Current Pharmaceutical Design Mediterranean Diet and the Metabolic Syndrome: The Role of Protein
Current Nutrition & Food Science The Double Roles of the Prostaglandin E<sub>2</sub> EP2 Receptor in Intracerebral Hemorrhage
Current Drug Targets Potential MicroRNA Targets for Cancer Chemotherapy
Current Medicinal Chemistry Dual or Single Antiplatelet Therapy After Transcatheter Aortic Valve Implantation? A Systematic Review and Meta-Analysis
Current Pharmaceutical Design An Overview on Fibroblast Growth Factors: Structural, Functional and Therapeutic Implications
Current Proteomics Effects of Dietary Coconut Oil on Erucic Acid Rich Rapeseed Oil-induced Changes of Blood Serum Lipids in Rats
Current Nutrition & Food Science Importance of Receptor-targeted Systems in the Battle Against Atherosclerosis
Current Pharmaceutical Design The Role of Inflammation in Epicardial Adipose Tissue in Heart Diseases
Current Pharmaceutical Design Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors
Current Topics in Medicinal Chemistry Odontogenic Infections in the Etiology of Infective Endocarditis
Cardiovascular & Hematological Disorders-Drug Targets Role of Micronutrients on Subclinical Atherosclerosis Micronutrients in Subclinical Atherosclerosis
Current Pharmaceutical Design Outline of Proteins and Signaling Pathways Involved in Heart Failure
Current Protein & Peptide Science