Pulmonary Coccidioidomycosis Complicated by Nontuberculous Mycobacterial Pulmonary Diseases with a Literature Review

Hiroki Ashizawa; Naoki Iwanaga; Hirokazu Kurohama; Yuya Ito; Nobuyuki Ashizawa; Tatsuro Hirayama; Kazuaki Takeda; Shotaro Ide; Yohsuke Nagayoshi; Masato Tashiro; Takahiro Takazono; Tsutomu Tagawa; Kiyoyasu Fukushima; Masahiro Ito; Shigeki Nakamura; Koichi Izumikawa; Katsunori Yanagihara; Yoshitsugu Miyazaki; Hiroshi Mukae

doi:10.7883/yoken.JJID.2023.073

Short Communication

Pulmonary Coccidioidomycosis Complicated by Nontuberculous Mycobacterial Pulmonary Diseases with a Literature Review

Hiroki Ashizawa, Naoki Iwanaga, Hirokazu Kurohama, Yuya Ito, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Yohsuke Nagayoshi, Masato Tashiro, Takahiro Takazono, Tsutomu Tagawa, Kiyoyasu Fukushima, Masahiro Ito, Shigeki Nakamura, Koichi Izumikawa, Katsunori Yanagihara, Yoshitsugu Miyazaki, Hiroshi Mukae

Author information

Hiroki Ashizawa
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Respiratory Medicine, Nagasaki Medical Center, Japan
Naoki Iwanaga
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Respiratory Medicine, Nagasaki Medical Center, Japan
Hirokazu Kurohama
Department of Pathology, Nagasaki University Hospital, Japan
Department of Pathology, National Hospital Organization, Nagasaki Medical Center, Japan
Yuya Ito
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Nobuyuki Ashizawa
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Infection Control and Education Center, Nagasaki University Hospital, Japan
Tatsuro Hirayama
Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Japan
Kazuaki Takeda
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Shotaro Ide
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Infectious Diseases Experts Training Center, Nagasaki University Hospital, Japan
Yohsuke Nagayoshi
Department of Respiratory Medicine, Nagasaki Medical Center, Japan
Division of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Japan
Masato Tashiro
Department of Infection Control and Education Center, Nagasaki University Hospital, Japan
Takahiro Takazono
Department of Respiratory Medicine, Nagasaki University Hospital, Japan
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tsutomu Tagawa
Department of Thoracic Surgery, National Hospital Organization, Nagasaki Medical Center, Japan
Kiyoyasu Fukushima
Division of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Japan
Masahiro Ito
Department of Pathology, National Hospital Organization, Nagasaki Medical Center, Japan
Shigeki Nakamura
Department of Microbiology, Tokyo Medical University, Japan
Department of Fungal Infection, National Institute of Infectious Diseases, Japan
Koichi Izumikawa
Department of Infection Control and Education Center, Nagasaki University Hospital, Japan
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Katsunori Yanagihara
Department of Laboratory Medicine, Nagasaki University Hospital, Japan
Yoshitsugu Miyazaki
Department of Fungal Infection, National Institute of Infectious Diseases, Japan
Hiroshi Mukae
Department of Respiratory Medicine, Nagasaki University Hospital, Japan

Keywords: coccidioidomycosis, nontuberculous mycobacterial pulmonary diseases, imported mycosis, history taking

JOURNAL FREE ACCESS

2023 Volume 76 Issue 5 Pages 314-318

DOI https://doi.org/10.7883/yoken.JJID.2023.073

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Abstract

Following an endobronchial examination, a young mine supervisor was treated with antibiotics for a pulmonary nontuberculous mycobacterial infection for approximately one year. However, a review of the radiological findings revealed a different possibility. Accordingly, pulmonary resection was performed, and histopathological analysis revealed numerous yeast-like fungi. Since the patient had stayed in the southwestern United States for two months in 2009, eight years previously, coccidioidomycosis was strongly suspected. The diagnosis of coccidioidomycosis was subsequently confirmed by serology and polymerase chain reaction testing of the excised specimen. Here, we report an educational case that emphasizes the importance of meticulous medical history-taking and awareness of endemic mycoses in other countries in the context of globalization.

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