Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan

Emi Takashita; Hiroko Morita; Shiho Nagata; Masayuki Shirakura; Seiichiro Fujisaki; Hideka Miura; Ikuyo Takayama; Tomoko Arita; Yasushi Suzuki; Masaoki Yamaoka; Taichiro Tanikawa; Ryota Tsunekuni; Junki Mine; Saki Sakuma; Yuko Uchida; Akihiro Shibata; Mari Iwanaka; Noriko Kishida; Kazuya Nakamura; Tsutomu Kageyama; Shinji Watanabe; Hideki Hasegawa; The Influenza Virus Surveillance Group of Japan

doi:10.7883/yoken.JJID.2021.751

Short Communications

Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan

Emi Takashita, Hiroko Morita, Shiho Nagata, Masayuki Shirakura, Seiichiro Fujisaki, Hideka Miura, Ikuyo Takayama, Tomoko Arita, Yasushi Suzuki, Masaoki Yamaoka, Taichiro Tanikawa, Ryota Tsunekuni, Junki Mine, Saki Sakuma, Yuko Uchida, Akihiro Shibata, Mari Iwanaka, Noriko Kishida, Kazuya Nakamura, Tsutomu Kageyama, Shinji Watanabe, Hideki Hasegawa, The Influenza Virus Surveillance Group of Japan

Author information

Emi Takashita
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Hiroko Morita
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Shiho Nagata
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Masayuki Shirakura
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Seiichiro Fujisaki
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Hideka Miura
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Ikuyo Takayama
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Tomoko Arita
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Yasushi Suzuki
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Masaoki Yamaoka
Hyogo Prefectural Institute of Public Health Science, Japan
Taichiro Tanikawa
Virus group, Division of Infectious Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
Ryota Tsunekuni
Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
Junki Mine
Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
Saki Sakuma
Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
Yuko Uchida
Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
Akihiro Shibata
Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Japan
Mari Iwanaka
Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Japan
Noriko Kishida
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Kazuya Nakamura
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Tsutomu Kageyama
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Shinji Watanabe
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
Hideki Hasegawa
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
The Influenza Virus Surveillance Group of Japan

Keywords: avian influenza, antiviral susceptibility, neuraminidase inhibitor, RNA polymerase inhibitor

JOURNAL FREE ACCESS

2022 Volume 75 Issue 4 Pages 398-402

DOI https://doi.org/10.7883/yoken.JJID.2021.751

Browse “Advance online publication” version

Details

Abstract

The circulation of avian influenza A viruses in poultry is a public health concern due to the potential transmissibility and severity of these viral infections. Monitoring the susceptibility of these viruses to antivirals is important for developing measures to strengthen the level of preparedness against influenza pandemics. However, drug susceptibility information on these viruses is limited. Here, we determined the susceptibilities of avian influenza A(H5N1), A(H5N2), A(H5N8), A(H7N7), A(H7N9), A(H9N1), and A(H9N2) viruses isolated in Japan to the antivirals approved for use there: an M2 inhibitor (amantadine), neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, and laninamivir) and RNA polymerase inhibitors (baloxavir and favipiravir). Genotypic methods that detect amino acid substitutions associated with antiviral resistance and phenotypic methods that assess phenotypic viral susceptibility to drugs have revealed that these avian influenza A viruses are susceptible to neuraminidase and RNA polymerase inhibitors. These results suggest that neuraminidase and RNA polymerase inhibitors currently approved in Japan could be a treatment option against influenza A virus infections in humans.

Corresponding author

Register with J-STAGE for free!