Japanese Journal of Infectious Diseases
Online ISSN : 1884-2836
Print ISSN : 1344-6304
ISSN-L : 1344-6304
Short Communications
Fluctuations in Antibody Titers against Enterovirus D68 in Pediatric Sera Collected in a Community before, during, and after a Possible Outbreak
Francois Marie Ngako Kadji, Hidekazu Nishimura, Michiko Okamoto, Ko Sato, Suguru Ohmiya, Hiroko Ito, Akira Suzuki, Yukio Nagai, Hitoshi Oshitani
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Keywords: enterovirus D68, neutralization antibody, children, outbreak, seroprevalence
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2020 Volume 73 Issue 1 Pages 55-57

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Abstract

We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0–6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children’s immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.

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