Multi-scale modelling of E. coli metabolism
1
Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, United Kingdom
2
INSA, UPS, INP, LISBP, INRA, UMR792 Ingenierie des Systemes Biologiques et des Procedes, CNRS, UMR550, Université de Toulouse, Toulouse, France
- Published
- Accepted
- Subject Areas
- Biochemistry, Computational Biology, Mathematical Biology
- Keywords
- metabolism, systems biology, modelling, simulation, Escherichia coli
- Copyright
- © 2015 Smallbone et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2015. Multi-scale modelling of E. coli metabolism. PeerJ PrePrints 3:e914v1 https://doi.org/10.7287/peerj.preprints.914v1
Abstract
In response to environmental and genetic perturbations, micro-organisms may regulate their metabolism both metabolically – via metabolite-enzyme interactions – and hierarchically – via modulating enzyme capacities. In this report, we develop a combined metabolic and genetic regulatory model of E. coli that may be used to test this multi-scale response.
Author Comment
This report is deliverable 4.6 of the EU FP7 (KBBE) grant 289434 "BioPreDyn: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications".