The neurodevelopmental trajectory of Borderline Personality Disorder: a review
- Published
- Accepted
- Subject Areas
- Neuroscience, Psychiatry and Psychology
- Keywords
- Borderline personality disorder, BPD, Neuroimaging, MRI, fMRI, DTI, PET, Review
- Copyright
- © 2018 Edinboro et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2018. The neurodevelopmental trajectory of Borderline Personality Disorder: a review. PeerJ Preprints 6:e27414v1 https://doi.org/10.7287/peerj.preprints.27414v1
Abstract
Borderline Personality Disorder (BPD) is a complex psychological condition characterised by affective instability, cognitive impairment, problematic behaviours and social dysfunction. Due to the variability in symptomatic profiles, efforts have recently been directed towards comprehending the disorder from a neurological standpoint within the aforementioned domains. Although adolescent-onset BPD is now reliably diagnosed as the adult-onset variant, a limited number of studies address the neural correlates of first presentation BPD. Moreover, research investigating the outcomes of therapeutic interventions on brain function and morphology is scarce. Preliminary findings consistently cite the involvement of grey matter deficiencies of the orbitofrontal cortex, hippocampus and amygdala in the neuropathology of BPD. Additionally, frontolimbic white matter deficits are thought to be implicated. Functionally, over-activity in limbic regions such as the cingulate cortices and amygdala are believed to partially account for emotion dysregulation, though the neural correlates of cognitive, social and behavioural impairments are relatively poorly understood. The present review will endeavour to evaluate the existing neurobiological evidence for BPD in adolescence as well as adulthood. Finally, a rudimentary neurodevelopmental model of BPD will be proposed.
Author Comment
This is a preprint submission to PeerJ Preprints. This version will be subject to change and we intend to submit the final version elsewhere.