Compile Data Set for Download or QSAR
maximum 50k data
Found 54 Enz. Inhib. hit(s) with all data for entry = 10587
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552729((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: <5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552708((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: <5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552703((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: <5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552704((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50: <5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552705((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l ,2,3-triazol-...)
Affinity DataIC50: <5nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552711((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-methylcyclopro...)
Affinity DataIC50:  10nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552726((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  10nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  10nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  10nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  10nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552706((2S,4R)-N-(l-(2-chloro-4-(4-methylthia7,ol-5-yl)ph...)
Affinity DataIC50:  10nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552731((2S, 4R)-N-((S)-l-(2'-chloro-[l,r-biphenyl]-4-yl)e...)
Affinity DataIC50:  10nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552687((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...)
Affinity DataIC50:  20nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552707((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50:  20nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552709((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  20nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552687((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...)
Affinity DataIC50:  20nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552712(WO2022103411, Compound 30 | WO2022103411, Example ...)
Affinity DataIC50:  20nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552728((2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-...)
Affinity DataIC50:  30nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552710((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-(trifluorometh...)
Affinity DataIC50:  40nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552725((2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-...)
Affinity DataIC50:  80nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552685((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  80nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552691((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  100nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552683((2S,4R)-N-((R)-3-([1,1'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  110nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552724((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  110nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552692((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  110nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552693((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  120nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552690((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  130nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552696(WO2022103411, Example S11)
Affinity DataIC50:  150nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552684((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  150nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552684((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  150nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552689((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  190nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552723((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  190nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552730((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  200nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552683((2S,4R)-N-((R)-3-([1,1'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  220nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552695((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  280nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552720(WO2022103411, Compound 38 | WO2022103411, Example ...)
Affinity DataIC50:  300nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552713(WO2022103411, Compound 31 | WO2022103411, Example ...)
Affinity DataIC50:  310nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552694((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  450nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552714((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  460nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552727((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50:  1.10E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552717(WO2022103411, Compound 35 | WO2022103411, Example ...)
Affinity DataIC50:  1.62E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552722((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  1.66E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552701(WO2022103411, Example S17 | l-((S)-l-((2S,4R)-2-((...)
Affinity DataIC50:  2.21E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552698((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  2.27E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552700(WO2022103411, Example S16 | l-((S)-l-((2S,4R)-2-((...)
Affinity DataIC50:  3.31E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552715((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  5.40E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552716(WO2022103411, Compound 34 | WO2022103411, Example ...)
Affinity DataIC50:  6.25E+3nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552688((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  1.51E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552685((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50:  2.07E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

WIPO
LigandPNGBDBM552721(WO2022103411, Compound 39 | WO2022103411, Example ...)
Affinity DataIC50:  6.85E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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