Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50030766
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  100nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  300nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301062(CHEMBL572098 | N-(2-cyclopropylethyl)-6-(4-(2-(tri...)
Affinity DataIC50:  300nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301061(6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)py...)
Affinity DataIC50:  700nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301065(2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide ...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301056(CHEMBL577119 | N-methyl-2-(4-(2-(trifluoromethyl)b...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301060(CHEMBL572306 | N-(2-cyclopropyl-2-hydroxyethyl)-6-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301058((4-(thiazol-2-yl)piperazin-1-yl)(2-(trifluoromethy...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301056(CHEMBL577119 | N-methyl-2-(4-(2-(trifluoromethyl)b...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301059(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA 6-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to delta-6 saturase in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301058((4-(thiazol-2-yl)piperazin-1-yl)(2-(trifluoromethy...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301064(CHEMBL583251 | N-(2-cyclopropylethyl)-2-(4-(2-(tri...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity to delta-5 saturase in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301059(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301063(CHEMBL584308 | N-(2-cyclopropylethyl)-2-(4-(2-(tri...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed