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Found 17 Enz. Inhib. hit(s) with all data for entry = 50010943
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20800(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant His-tagged full length human HSP90 (9 to 236 residues) expressed in Escherichia coli BL21(DE3) cells after 18 hrs by fluore...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543601(CHEMBL2134202)
Affinity DataKi:  20nMAssay Description:Inhibition of S6K1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50088378(Afinitor | Afinitor Disperz | CHEBI:68478 | Everol...)
Affinity DataIC50:  5nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Vps34 (unknown origin) interaction with PIK3 assessed as reduction in autophagy by increasing LC3 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50:  19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543600(CHEMBL4639853)
Affinity DataIC50:  19nMAssay Description:Inhibition of Vps34 in human MCF7-LC3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  21nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543600(CHEMBL4639853)
Affinity DataIC50:  40nMAssay Description:Inhibition of Vps34 in human MCF7-LC3 cells assessed as rapamycin-induced autophagyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50:  51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543600(CHEMBL4639853)
Affinity DataIC50:  90nMAssay Description:Inhibition of Vps34 in human MCF7-LC3 cells assessed as starvation-induced autophagyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50543601(CHEMBL2134202)
Affinity DataIC50:  160nMAssay Description:Inhibition of S6K1 (unknown origin)More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)
Affinity DataIC50:  970nMAssay Description:Induction of UGT1A1 (unknown origin) assessed as increase in intracellular acidic autophagy vesicles formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50205338(CHEMBL3948237)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of GST/His-tagged human KEAP1 (321 to 609 residues) interaction with phosphorylated p62 expressed in Escherichia coli cells by fluorescenc...More data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human DNA polymerase-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50017716(2,2-Diphenyl-pentanoic acid 2-diethylamino-ethyl e...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed