Found 30 Enz. Inhib. hit(s) with all data for entry = 50001390 
Affinity DataIC50: 100nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of AKR1C3 (unknown origin) using S-tetralol as substrate in presence of NADP+ by fluorimteryMore data for this Ligand-Target Pair
3D Structure (crystal)TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of type-1 human steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 3.56E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 8.63E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 1.32E+4nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 3.28E+4nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 (DE) using [14C]androstenedione as substrate in presence of NADPH generatin...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 6.29E+4nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 7.06E+4nMAssay Description:Inhibition of AKR1C2 (unknown origin) using S-tetralol as substrate by by fluorimteryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Torino
Curated by ChEMBL
University Of Torino
Curated by ChEMBL
Affinity DataIC50: 7.32E+4nMAssay Description:Inhibition of AKR1C2 (unknown origin) using S-tetralol as substrate by by fluorimteryMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
