Compile Data Set for Download or QSAR
maximum 50k data
Found 61 Enz. Inhib. hit(s) with all data for entry = 50041886
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310150((S)-2-amino-4-(2,6-diethylpyridin-4-yl)-4-(3-(2-fl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303717(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50417810(CHEMBL1651460)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310158(CHEMBL598259 | rac-2-amino-4-(2-ethylpyridin-4-yl)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303739(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310152(CHEMBL597277 | rac-2-amino-4-(2,6-diethylpyridin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303750(2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303738(2-amino-4-(4-methoxy-3-(trifluoromethyl)phenyl)-1-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303745(2-amino-4-(3-fluoro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303722(2-amino-4-(4-methoxy-3-propoxyphenyl)-1-methyl-4-(...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303752(2-amino-4-(3-butoxy-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303749(2-amino-4-(3-ethoxy-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303723(2-amino-4-(3-isopropoxy-4-methoxyphenyl)-1-methyl-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303757(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310155(2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyr...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310159(CHEMBL590492 | rac-2-amino-4-(2-isopropylpyridin-4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50314612(2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303744(2-amino-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-1-m...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310157(CHEMBL598258 | rac-2-amino-1-methyl-4-(2-methylpyr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303733(2-amino-4-(3,4-dimethoxyphenyl)-1-methyl-4-(3-(pyr...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303751(2-amino-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310156(CHEMBL598257 | rac-2-amino-1-methyl-4-(2-methylpyr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303758(2-amino-4-(2,3-dihydrobenzofuran-5-yl)-1-methyl-4-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303724(2-amino-4-(3-cyclopentyl-4-methoxyphenyl)-1-methyl...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303720(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(4...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310151(CHEMBL597062 | rac-2-amino-4-(2,6-dimethylpyridin-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50310160(CHEMBL603664 | rac-2-amino-4-(2-ethyl-6-methylpyri...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303736(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303742(5-Adamantan-1-yl-2-amino-5-(3,4-dimethoxy-phenyl)-...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303748((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303721(5-Adamantan-1-yl-2-amino-5-(4-ethoxy-phenyl)-3-met...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303732(5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluorome...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303737(5-Adamantan-1-yl-2-amino-5-(4-butoxy-phenyl)-3-met...)
Affinity DataIC50:  871nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303730(2-amino-4-(3-(6-methoxypyridin-3-yl)phenyl)-1-meth...)
Affinity DataIC50:  899nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50305477(6-(2-amino-4-cyclohexyl-5-oxo-4-phenyl-4,5-dihydro...)
Affinity DataIC50:  951nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50305467(2-amino-4-cyclohexyl-1-methyl-4-phenyl-1H-imidazol...)
Affinity DataIC50:  991nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50305481(2-amino-4-cyclohexyl-4-phenyl-1-((tetrahydrofuran-...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50305480(2-amino-4-cyclohexyl-1-(3,5-difluorobenzyl)-4-phen...)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50305479(2-amino-1-benzyl-4-cyclohexyl-4-phenyl-1H-imidazol...)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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