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Compile Data Set for Download or QSAR
maximum 50k data
Found
37
Enz. Inhib. hit(s) with all data for entry = 5231
Target
Adenosine receptor A2a
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM21190
(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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MCE
PC cid
PC sid
PDB
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Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50207816
(CHEMBL273094 | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1...)
Copy SMILES
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Affinity Data
Ki: 7.30nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MMDB
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PC sid
PDB
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PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM81971
(1,3-Diethyl-8-phenyl-3,7-dihydro-purine-2,6-dione ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12.3nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
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PubMed
Copy BDB DOI
Target
Adenosine receptor A3
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82558
(CAS_163889 | CHEMBL355370 | I-ABOPX | NSC_163889)
Copy SMILES
Copy InChI
Affinity Data
Ki: 15nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82558
(CAS_163889 | CHEMBL355370 | I-ABOPX | NSC_163889)
Copy SMILES
Copy InChI
Affinity Data
Ki: 30nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM21190
(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 31nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM21190
(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 31.6nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82558
(CAS_163889 | CHEMBL355370 | I-ABOPX | NSC_163889)
Copy SMILES
Copy InChI
Affinity Data
Ki: 40nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82032
(1,3-Dipropyl-3,7-dihydro-purine-2,6-dione | 1,3-Di...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM85036
(BW-A1433 | BWA1433 | CAS_129447 | NSC_129447)
Copy SMILES
Copy InChI
Affinity Data
Ki: 51.6nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82032
(1,3-Dipropyl-3,7-dihydro-purine-2,6-dione | 1,3-Di...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 56nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A1
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82558
(CAS_163889 | CHEMBL355370 | I-ABOPX | NSC_163889)
Copy SMILES
Copy InChI
Affinity Data
Ki: 70nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2a
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82558
(CAS_163889 | CHEMBL355370 | I-ABOPX | NSC_163889)
Copy SMILES
Copy InChI
Affinity Data
Ki: 95nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2a
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82032
(1,3-Dipropyl-3,7-dihydro-purine-2,6-dione | 1,3-Di...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 156nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A3
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM21190
(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 269nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM21220
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
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Affinity Data
Ki: 330nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Adenosine receptor A3
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM82032
(1,3-Dipropyl-3,7-dihydro-purine-2,6-dione | 1,3-Di...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 509nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A1
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM21190
(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 536nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2a
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.20E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
PubMed
DrugBank
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Adenosine receptor A1
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.20E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.30E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.40E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.85E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.20E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM35804
((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
PDB
Patents
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50006730
((R)-2-Hydroxymethyl-5-[6-(1-methyl-2-phenyl-ethyla...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM85527
(S-N6-(2-phenylisopropyl) adenosine)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM85525
(AB-NECA)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50085658
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50003588
((2-CADO) 2-(6-Amino-2-chloro-purin-9-yl)-5-hydroxy...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
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In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2a
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A3
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A1
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
DrugBank
Copy BDB DOI
Target
Adenosine receptor A3
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM25400
((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
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In Depth
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PubMed
Copy BDB DOI
Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM85526
(CAS_190964 | I-APE | NSC_190964)
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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PubMed
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Target
Adenosine receptor A2b
(Homo sapiens (Human))
University Of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50034171
(3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl...)
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Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
Copy BDB DOI