Compile Data Set for Download or QSAR
maximum 50k data
Found 72 Enz. Inhib. hit(s) with all data for entry = 50015652
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM488485(US10954243, Example 16)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM488485(US10954243, Example 16)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588244(CHEMBL5176625)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588244(CHEMBL5176625)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588242(CHEMBL5192885)
Affinity DataIC50:  6nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588232(CHEMBL5180399)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  12nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588243(CHEMBL5183827)
Affinity DataIC50:  17nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588231(CHEMBL5196141)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588243(CHEMBL5183827)
Affinity DataIC50:  22nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588222(CHEMBL5179772)
Affinity DataIC50:  32nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588242(CHEMBL5192885)
Affinity DataIC50:  35nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM516917(US11104675, Example 9)
Affinity DataIC50:  45nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM516917(US11104675, Example 9)
Affinity DataIC50:  48nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  53nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588233(CHEMBL5172365)
Affinity DataIC50:  56nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588242(CHEMBL5192885)
Affinity DataIC50:  60nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588236(CHEMBL5189709)
Affinity DataIC50:  78nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588252(CHEMBL5188744)
Affinity DataIC50:  87nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588222(CHEMBL5179772)
Affinity DataIC50:  89nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588254(CHEMBL5203457)
Affinity DataIC50:  89nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588252(CHEMBL5188744)
Affinity DataIC50:  94nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  100nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  100nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588237(CHEMBL5196693)
Affinity DataIC50:  101nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588223(CHEMBL5198852)
Affinity DataIC50:  105nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497004(US11001561, Compound 3 | US11001561, Compound 3a |...)
Affinity DataIC50:  122nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497004(US11001561, Compound 3 | US11001561, Compound 3a |...)
Affinity DataIC50:  122nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497004(US11001561, Compound 3 | US11001561, Compound 3a |...)
Affinity DataIC50:  123nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588235(CHEMBL5182453)
Affinity DataIC50:  129nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588228(CHEMBL5208899)
Affinity DataIC50:  147nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588240(CHEMBL5202318)
Affinity DataIC50:  210nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588254(CHEMBL5203457)
Affinity DataIC50:  223nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588239(CHEMBL5174916)
Affinity DataIC50:  225nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM488485(US10954243, Example 16)
Affinity DataIC50:  230nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588229(CHEMBL5181129)
Affinity DataIC50:  350nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497029(US11001561, Compound 24 | US11104675, Example 11 |...)
Affinity DataIC50:  366nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497001(US11001561, Compound 2 | US11104675, Example 1 | U...)
Affinity DataIC50:  517nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497001(US11001561, Compound 2 | US11104675, Example 1 | U...)
Affinity DataIC50:  557nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM497029(US11001561, Compound 24 | US11104675, Example 11 |...)
Affinity DataIC50:  625nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588224(CHEMBL5204587)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588238(CHEMBL5183888)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588244(CHEMBL5176625)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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