Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50027268
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28118(3-cyanoquinoline, 3 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274438(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274439(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274204(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274440(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274335(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274333(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  11nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  12nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274384(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274334(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274332(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  21nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274386(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  25nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274245(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274437(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  33nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274202(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  35nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274203(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  36nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274244(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  52nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274243(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  55nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Src (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  58nMAssay Description:Inhibition of Lyn (unknown origin) in presence of 20 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274242(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  59nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  225nMAssay Description:Inhibition of MEK1-mediated ERK phosphorylation in human WM266-4 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of B-raf (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  9.17E+3nMAssay Description:Inhibition of IKKbeta (unknown origin) in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of P70S6 (unknown origin) in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50:  2.74E+4nMAssay Description:Inhibition of PKCtheta (unknown origin) in presence of 6 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of AKT (unknown origin) in presence of 20 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of Tpl2 (unknown origin) in presence of 50 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MK2 (unknown origin) in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed