Compile Data Set for Download or QSAR
maximum 50k data
Found 132 Enz. Inhib. hit(s) with all data for entry = 50021947
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229655(CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydro...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229651((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229641(CHEMBL400528 | pyrrolidin-3-yl 4-((4-(4-cyano-2-me...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229634((S)-tetrahydrofuran-3-yl 4-((4-(4-cyanophenyl)pipe...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229651((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229636((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229643((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229641(CHEMBL400528 | pyrrolidin-3-yl 4-((4-(4-cyano-2-me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229643((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229635(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229655(CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydro...)
Affinity DataIC50:  16nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229656(CHEMBL252612 | pyrrolidin-3-yl 4-(hydroxycarbamoyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229650((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229640((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229656(CHEMBL252612 | pyrrolidin-3-yl 4-(hydroxycarbamoyl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229644((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  18nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229647((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229646((R)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)
Affinity DataIC50:  19nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229644((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  22nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229644((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  22nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229635(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)
Affinity DataIC50:  22nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229636((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  23nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229661((S)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)
Affinity DataIC50:  23nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229647((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  24nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  25nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229654((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  25nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229654((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  26nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229645((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  27nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229644((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  28nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229646((R)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)
Affinity DataIC50:  30nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229645((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  34nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229661((S)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)
Affinity DataIC50:  34nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50:  36nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229634((S)-tetrahydrofuran-3-yl 4-((4-(4-cyanophenyl)pipe...)
Affinity DataIC50:  39nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229650((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  41nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229642((S)-tetrahydrofuran-3-yl 4-((4-(2-fluorophenyl)pip...)
Affinity DataIC50:  44nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229663((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  45nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229659((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  52nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229648((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...)
Affinity DataIC50:  57nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229642((S)-tetrahydrofuran-3-yl 4-((4-(2-fluorophenyl)pip...)
Affinity DataIC50:  76nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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