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Found 127 Enz. Inhib. hit(s) with all data for entry = 50031804
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319622(CHEMBL1083152 | N,4-Dimethyl-5-(2-(3,4,5-trimethox...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319622(CHEMBL1083152 | N,4-Dimethyl-5-(2-(3,4,5-trimethox...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  4nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319619(4-(2,4-Dimethylthiazol-5-yl)-N-(4-morpholinophenyl...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319620(CHEMBL1084715 | N-(4-(4-(2-(Ethylamino)-4-methylth...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319620(CHEMBL1084715 | N-(4-(4-(2-(Ethylamino)-4-methylth...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319617(CHEMBL1084630 | N-Ethyl-4-methyl-5-(2-(4-morpholin...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319621(CHEMBL1086088 | N-Ethyl-4-methyl-5-(2-(3,4,5-trime...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319622(CHEMBL1083152 | N,4-Dimethyl-5-(2-(3,4,5-trimethox...)
Affinity DataKi:  6nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319627(1-(4-(4-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-y...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319619(4-(2,4-Dimethylthiazol-5-yl)-N-(4-morpholinophenyl...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319620(CHEMBL1084715 | N-(4-(4-(2-(Ethylamino)-4-methylth...)
Affinity DataKi:  9nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319626(4-(2,4-Dimethylthiazol-5-yl)-N-(4-(4-(methylsulfon...)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319618(CHEMBL1084629 | N,4-Dimethyl-5-(2-(4-morpholinophe...)
Affinity DataKi:  9.40nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319615(1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)p...)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  11nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319615(1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)p...)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319627(1-(4-(4-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-y...)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319617(CHEMBL1084630 | N-Ethyl-4-methyl-5-(2-(4-morpholin...)
Affinity DataKi:  14nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319626(4-(2,4-Dimethylthiazol-5-yl)-N-(4-(4-(methylsulfon...)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319618(CHEMBL1084629 | N,4-Dimethyl-5-(2-(4-morpholinophe...)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319615(1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)p...)
Affinity DataKi:  22nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  31nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319620(CHEMBL1084715 | N-(4-(4-(2-(Ethylamino)-4-methylth...)
Affinity DataKi:  32nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319620(CHEMBL1084715 | N-(4-(4-(2-(Ethylamino)-4-methylth...)
Affinity DataKi:  38nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataKi:  44nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataKi:  44nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  53nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  57nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  70nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  73nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  80nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319617(CHEMBL1084630 | N-Ethyl-4-methyl-5-(2-(4-morpholin...)
Affinity DataKi:  151nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319618(CHEMBL1084629 | N,4-Dimethyl-5-(2-(4-morpholinophe...)
Affinity DataKi:  156nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  168nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319620(CHEMBL1084715 | N-(4-(4-(2-(Ethylamino)-4-methylth...)
Affinity DataKi:  171nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319617(CHEMBL1084630 | N-Ethyl-4-methyl-5-(2-(4-morpholin...)
Affinity DataKi:  196nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel Ltd

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  239nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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