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Found 41 Enz. Inhib. hit(s) with all data for entry = 50031782
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319070((2S,3R,4R,5S,6R)-2-(3-((6-(1,3,4-thiadiazol-2-yl)p...)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319048((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(methylthio)pyr...)
Affinity DataIC50:  13.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319044((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(pentyloxy)pyri...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319045((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(hexyloxy)pyrid...)
Affinity DataIC50:  17.3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319039((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-ethoxypyridazin...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319060((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(furan-3-yl)pyr...)
Affinity DataIC50:  61.3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319059((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(furan-2-yl)pyr...)
Affinity DataIC50:  64.3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319067((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(pyridin-3-yl)p...)
Affinity DataIC50:  64.9nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319040((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-propoxypyridazi...)
Affinity DataIC50:  70.8nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319049((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(ethylthio)pyri...)
Affinity DataIC50:  71.3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319061((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(thiophen-2-yl)...)
Affinity DataIC50:  71.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319062((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(thiophen-3-yl)...)
Affinity DataIC50:  75.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319047((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(tetrahydro-2H-...)
Affinity DataIC50:  77.6nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319068((2S,3R,4R,5S,6R)-2-(3-((6-(benzo[d][1,3]dioxol-5-y...)
Affinity DataIC50:  82.7nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319069((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(2,3-dihydroben...)
Affinity DataIC50:  103nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319042((2S,3R,4R,5S,6R)-2-(3-((6-butoxypyridazin-3-yl)met...)
Affinity DataIC50:  109nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319041((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isopropoxypyrid...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319046((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(cyclohexyloxy)...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319052((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-ethylpyridazin-...)
Affinity DataIC50:  131nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319057((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-pentylpyridazin...)
Affinity DataIC50:  134nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319063((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(5-methylthioph...)
Affinity DataIC50:  168nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319058((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(phenylethynyl)...)
Affinity DataIC50:  176nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319038((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin...)
Affinity DataIC50:  202nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319064((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-phenylpyridazin...)
Affinity DataIC50:  222nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319053((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-propylpyridazin...)
Affinity DataIC50:  237nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319054((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isopropylpyrida...)
Affinity DataIC50:  259nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319065((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(4-fluorophenyl...)
Affinity DataIC50:  272nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319051((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-methylpyridazin...)
Affinity DataIC50:  293nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319066((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(3-methoxypheny...)
Affinity DataIC50:  351nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319055((2S,3R,4R,5S,6R)-2-(3-((6-butylpyridazin-3-yl)meth...)
Affinity DataIC50:  356nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319043((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isobutoxypyrida...)
Affinity DataIC50:  435nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319072((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-morpholinopyrid...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319056((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isobutylpyridaz...)
Affinity DataIC50:  811nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319074((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(pyrrolidin-1-y...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM103008(CHEMBL1082417 | US8541380, 185)
Affinity DataIC50:  1.14E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319075((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-methyl-6-(methy...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319071((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(5-methyloxazol...)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319050((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(phenylthio)pyr...)
Affinity DataIC50:  1.87E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319076((2S,3R,4R,5S,6R)-2-(4-chloro-3-((4,5-dimethyl-6-(m...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Green Cross

Curated by ChEMBL
LigandPNGBDBM50319077((2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-methylphthalazi...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed