Compile Data Set for Download or QSAR
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Found 9 Enz. Inhib. hit(s) with all data for entry = 8335
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50:  680nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241948(US9428466, 4'-hydroxy-2-oxo-desthiomerbarone)
Affinity DataIC50:  1.06E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM46100(6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carb...)
Affinity DataIC50:  1.20E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50:  2.13E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetSolute carrier family 22 member 12(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241948(US9428466, 4'-hydroxy-2-oxo-desthiomerbarone)
Affinity DataIC50:  2.60E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  5.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50:  9.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  2.74E+5nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM46100(6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carb...)
Affinity DataIC50: >3.00E+5nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In DepthDetails US Patent