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Found 18 Enz. Inhib. hit(s) with all data for entry = 50046133
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50274835(CHEMBL511857 | trans-1-(4-(3-methoxyphenyl)cyclohe...)
Affinity DataKi:  0.0280nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  0.160nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50033843(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Affinity DataKi:  0.310nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107234(1-[3-(5-Methoxy-naphthalen-1-yl)-propyl]-4-pyridin...)
Affinity DataKi:  0.380nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50033852(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  0.480nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107245(1-[4-(3-Methoxy-phenyl)-butyl]-4-pyridin-2-yl-pipe...)
Affinity DataKi:  23nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50274835(CHEMBL511857 | trans-1-(4-(3-methoxyphenyl)cyclohe...)
Affinity DataEC50:  0.324nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50033843(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Affinity DataEC50:  3.39E+3nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50033843(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataEC50:  51nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107234(1-[3-(5-Methoxy-naphthalen-1-yl)-propyl]-4-pyridin...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50033852(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataEC50:  0.776nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute and Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50274835(CHEMBL511857 | trans-1-(4-(3-methoxyphenyl)cyclohe...)
Affinity DataEC50:  0.794nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed