Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 50033115
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339798((+/-)-5-(1H-Benzo[d]imidazol-1-yl)-3-(1-(2-(triflu...)
Affinity DataIC50: <9nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM28216(5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodia...)
Affinity DataIC50: <9nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339795(5-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidaz...)
Affinity DataIC50: <9nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM28216(5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodia...)
Affinity DataIC50:  25nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM28216(5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodia...)
Affinity DataIC50:  50nMAssay Description:Inhibition of NEK2 autophosphorylation preincubated with compound by DELFIA assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339794((+/-)-5-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  66nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339793(3-(benzyloxy)-5-(6-(1-methylpiperidin-4-yloxy)-1H-...)
Affinity DataIC50:  69nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM28216(5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodia...)
Affinity DataIC50:  160nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339799((+/-)-4-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  190nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM28216(5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodia...)
Affinity DataIC50:  200nMAssay Description:Inhibition of NEK2 assessed as inhibition of substrate phosphorylation preincubated for 5 mins before addition of substrate by DELFIA assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339800((+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  230nMAssay Description:Inhibition of NEK2 autophosphorylation preincubated with compound by DELFIA assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339801((R)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]im...)
Affinity DataIC50:  360nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339803((+/-)-4-(5-(3-(Dimethylamino)propoxy)-1H-benzo[d]i...)
Affinity DataIC50:  380nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339800((+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  570nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339799((+/-)-4-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  660nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339800((+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  910nMAssay Description:Inhibition of NEK2 assessed as inhibition of substrate phosphorylation preincubated for 5 mins before addition of substrate by DELFIA assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339795(5-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidaz...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339796(3-Methoxy-5-(6-(1-methylpiperidin-4-yloxy)-1H-benz...)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339804((+/-)-4-(5-(1-Cyclopropylpiperidin-4-yloxy)-1H-ben...)
Affinity DataIC50:  2.56E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339802((S)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]im...)
Affinity DataIC50:  4.86E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339797(5-(1H-Benzo[d]imidazol-1-yl)-3-methoxythiophene-2-...)
Affinity DataIC50:  5.31E+3nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339793(3-(benzyloxy)-5-(6-(1-methylpiperidin-4-yloxy)-1H-...)
Affinity DataIC50:  5.43E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339794((+/-)-5-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  6.57E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339803((+/-)-4-(5-(3-(Dimethylamino)propoxy)-1H-benzo[d]i...)
Affinity DataIC50:  1.52E+4nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339798((+/-)-5-(1H-Benzo[d]imidazol-1-yl)-3-(1-(2-(triflu...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339801((R)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]im...)
Affinity DataIC50:  5.13E+4nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339796(3-Methoxy-5-(6-(1-methylpiperidin-4-yloxy)-1H-benz...)
Affinity DataIC50:  6.44E+4nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339797(5-(1H-Benzo[d]imidazol-1-yl)-3-methoxythiophene-2-...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50339800((+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]...)
Affinity DataIC50:  8.79E+4nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed