Altersetin, a New Antibiotic from Cultures of Endophytic Alternaria spp. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activities

VERONIKA HELLWIG; TORSTEN GROTHE; ANKE MAYER-BARTSCHMID; RAINER ENDERMANN; FRANK-ULRICH GESCHKE; THOMAS HENKEL; MARC STADLER

doi:10.7164/antibiotics.55.881

Altersetin, a New Antibiotic from Cultures of Endophytic Alternaria spp.

Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activities

VERONIKA HELLWIG, TORSTEN GROTHE, ANKE MAYER-BARTSCHMID, RAINER ENDERMANN, FRANK-ULRICH GESCHKE, THOMAS HENKEL, MARC STADLER

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JOURNAL FREE ACCESS

2002 Volume 55 Issue 10 Pages 881-892

DOI https://doi.org/10.7164/antibiotics.55.881

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Abstract

A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.

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