Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp. II. Isolation and Structure Elucidation

YOICHI NAGANO; KOJI IKEDO; AKIRA FUJISHIMA; MOTOWO IZAWA; SHIGETOSHI TSUBOTANI; OSAMU NISHIMURA; MASAHIKO FUJINO

doi:10.7164/antibiotics.54.934

Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp.

II. Isolation and Structure Elucidation

YOICHI NAGANO, KOJI IKEDO, AKIRA FUJISHIMA, MOTOWO IZAWA, SHIGETOSHI TSUBOTANI, OSAMU NISHIMURA, MASAHIKO FUJINO

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 11 Pages 934-947

DOI https://doi.org/10.7164/antibiotics.54.934

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Abstract

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A₁ A₂, B, C and D were isolated from Bacillus sp. HC-70 and Bacillus sp. HC-72 by column chromatographies using adsorption and ion exchange resins. Their structures have been elucidated based on spectroscopic and degradation studies and shown to be peptide-like compounds. These compounds contained two unusual amino acids, viz., 5-amino-2, 3, 4, 6-tetrahydroxyhexanoic acid and 3-amino-3-phenylpropionic acid (β-phenylalanine). The structure-activity relationship studies suggested that 3-(5-amino-2, 3, 4, 6-tetrahydroxyhexanoyl)amino-3-phenylpropiomc acid moiety was essential for anti-H. pylori activity,

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