Biotransformation of Selamectin with Streptomyces lydicus SX-1298 Using a Novel Static Agar Fermentation System with Reemay® Mesh

MICHAEL S. PACEY; MARION M. BARNES; ROBERT A. MONDAY; MICHAEL RITZAU; ELIZABETH M. H. WELLINGTON

doi:10.7164/antibiotics.54.448

Biotransformation of Selamectin with Streptomyces lydicus SX-1298 Using a Novel Static Agar Fermentation System with Reemay^® Mesh

MICHAEL S. PACEY, MARION M. BARNES, ROBERT A. MONDAY, MICHAEL RITZAU, ELIZABETH M. H. WELLINGTON

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 5 Pages 448-454

DOI https://doi.org/10.7164/antibiotics.54.448

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Abstract

A novel approach to biotransformation is described using a solid medium matrix and Reemay^® mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a series of hydroxylations and an O-demethylation is described for selamectin the first endectocide for cats and dogs.

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