Xanthoquinodin B3, a New Anticoccidial Agent Produced by Humicola sp. FO-888

NORIKO TABATA; HIROSHI TOMODA; YUZURU IWAI; SATOSHI OMURA

doi:10.7164/antibiotics.49.267

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Xanthoquinodin B3, a New Anticoccidial Agent Produced by Humicola sp. FO-888

NORIKO TABATA, HIROSHI TOMODA, YUZURU IWAI, SATOSHI OMURA

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1996 Volume 49 Issue 3 Pages 267-271

DOI https://doi.org/10.7164/antibiotics.49.267

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Abstract

Xanthoquinodin B3, a new component of anticoccidial xanthoquinodins, which was detected in the culture broth of Humicola sp. FO-888, was isolated by heat treatment of the xanthoquinodins complex. Structural elucidation indicated that Xanthoquinodin B3 has the same heterodimer of xanthone- and anthraquinone-derived monomers as other xanthoquinodins. Schizont formation of monensin-resistant Eimeria tenella in BHK-21 cells was inhibited by Xanthoquinodin B3 at concentrations greater than 0.035μM.

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