The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Screening for Apoptosis Inducers in Microbial Products and Induction of Apoptosis by Cytostatin
KATSUHISA YAMAZAKI, MASAHIDE AMEMIYA, MASAAKI ISHIZUKA, TOMIO TAKEUCHI
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JOURNAL FREE ACCESS

1995 Volume 48 Issue 10 Pages 1138-1140

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Abstract

We have employed the DNA-methylgreen binding assay as a primary screening method for identifying apoptosis inducers in microbial products. Capsimycin, toyocamycin and cytostatin affect the binding of methylgreen to DNA of FS3 cells in this test system. The effect of cytostatin on apoptosis induction was confirmed by means of the ELISA system.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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