A Novel Bioactive δ lactone FD-211 Taxonomy, Isolation and Characterization

OSAMU NOZAWA; TADAYASU OKAZAKI; NORIYOSHI SAKAI; TOSHI KOMURASAKI; KAZUNORI HANADA; SHIGEO MORIMOTO; ZENG-XIANG CHEN; BI-MEI HE; KAZUTOSHI MIZOUE

doi:10.7164/antibiotics.48.113

A Novel Bioactive δ lactone FD-211

Taxonomy, Isolation and Characterization

OSAMU NOZAWA, TADAYASU OKAZAKI, NORIYOSHI SAKAI, TOSHI KOMURASAKI, KAZUNORI HANADA, SHIGEO MORIMOTO, ZENG-XIANG CHEN, BI-MEI HE, KAZUTOSHI MIZOUE

Author information

OSAMU NOZAWA
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.
TADAYASU OKAZAKI
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.
NORIYOSHI SAKAI
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.
TOSHI KOMURASAKI
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.
KAZUNORI HANADA
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.
SHIGEO MORIMOTO
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.
ZENG-XIANG CHEN
Department of New antibiotics, Sichuan Industrial Institute of Antibiotics
BI-MEI HE
Department of New antibiotics, Sichuan Industrial Institute of Antibiotics
KAZUTOSHI MIZOUE
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1995 Volume 48 Issue 2 Pages 113-118

DOI https://doi.org/10.7164/antibiotics.48.113

Details

Abstract

During our screening program for natural product drugs effective against multidrug-resistant mammalian cells, we have discovered a new δ lactone FD-211 from the fermantation broth of Myceliophthora lutea TF-0409. FD-211 had a broad spectrum activity against cultured tumor cell lines, including adriamycin-resistant HL-60 cells.

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