DACTYLFUNGINS, NOVEL ANTIFUNGAL ANTIBIOTICS PRODUCED BY Dactylaria parvispora

JIN-ZHONG XAIO; SHIGENORI KUMAZAWA; NOBUJI YOSHIKAWA; TAKASHI MIKAWA; YOSHIKAZU SATO

doi:10.7164/antibiotics.46.48

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

DACTYLFUNGINS, NOVEL ANTIFUNGAL ANTIBIOTICS PRODUCED BY Dactylaria parvispora

JIN-ZHONG XAIO, SHIGENORI KUMAZAWA, NOBUJI YOSHIKAWA, TAKASHI MIKAWA, YOSHIKAZU SATO

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1993 Volume 46 Issue 1 Pages 48-55

DOI https://doi.org/10.7164/antibiotics.46.48

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Abstract

Novel antifungal antibiotics, designated as dactylfungins A (1) and B (3), were isolated from the culture broth of Dactylaria parvispora D500. Dactylfungins A and B were found to be new substances containing an α-pyrone and a γ-pyrone ring, respectively, which conjoined with a polyalcohol moiety and a long side chain, based on NMR spectral analyses. The antibiotics were active against Candida pseudotropicalis and other fungi, with an MIC value at less than 10 μg/ml.

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