DUNAIMYCINS, A NEW COMPLEX OF SPIROKETAL 24-MEMBERED MACROLIDES WITH IMMUNOSUPPRESSIVE ACTIVITY II. ISOLATION AND ELUCIDATION OF STRUCTURES

JILL E. HOCHLOWSKI; MARK M. MULLALLY; GREGORY M. BRILL; DAVID N. WHITTERN; ALEX M. BUKO; PRESTON HILL; JAMES B. MCALPINE

doi:10.7164/antibiotics.44.1318

DUNAIMYCINS, A NEW COMPLEX OF SPIROKETAL 24-MEMBERED MACROLIDES WITH IMMUNOSUPPRESSIVE ACTIVITY

II. ISOLATION AND ELUCIDATION OF STRUCTURES

JILL E. HOCHLOWSKI, MARK M. MULLALLY, GREGORY M. BRILL, DAVID N. WHITTERN, ALEX M. BUKO, PRESTON HILL, JAMES B. MCALPINE

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 12 Pages 1318-1330

DOI https://doi.org/10.7164/antibiotics.44.1318

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Abstract

A novel complex of antifungal and immunosuppressant compounds has been isolated from the fermentation broth and mycelia of two strains of Streptomyces diastatochromogenes. The structures of eight related components were determined employing 1D and 2D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. These structures represent the first reported spiroketal 24-membered macrolide natural products related to the common 26-membered oligomycins.

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