CHEMICAL AND BIOLOGICAL PROPERTIES OF RUBIGINONE, A COMPLEX OF NEW ANTIBIOTICS WITH VINCRISTINE-CYTOTOXICITY

MASAHISA OKA; HIDEO KAMEI; YASUTARO HAMAGISHI; KOJI TOMITA; TAKEO MIYAKI; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.43.967

MASAHISA OKA, HIDEO KAMEI, YASUTARO HAMAGISHI, KOJI TOMITA, TAKEO MIYAKI, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 8 Pages 967-976

DOI https://doi.org/10.7164/antibiotics.43.967

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Abstract

A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A₁, A₂, B₁, B₂, C₁ and C₂. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.

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