HATOMAMICIN (YL-0358M-A), A NEW ALKALOID ANTIBIOTIC: FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

HARUMITSU IMAI; SHIGEO FUJITA; KENICHI SUZUKI; MOTO MORIOKA; TATSUHIRO TOKUNAGA; MINORU SHIMIZU; SHIGENOBU KADOTA; TOSHIO FURUYA; TAKESHI SAITO

doi:10.7164/antibiotics.42.1043

HARUMITSU IMAI, SHIGEO FUJITA, KENICHI SUZUKI, MOTO MORIOKA, TATSUHIRO TOKUNAGA, MINORU SHIMIZU, SHIGENOBU KADOTA, TOSHIO FURUYA, TAKESHI SAITO

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HARUMITSU IMAI
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
SHIGEO FUJITA
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
KENICHI SUZUKI
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
MOTO MORIOKA
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
TATSUHIRO TOKUNAGA
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
MINORU SHIMIZU
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
SHIGENOBU KADOTA
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
TOSHIO FURUYA
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
TAKESHI SAITO
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1989 Volume 42 Issue 7 Pages 1043-1048

DOI https://doi.org/10.7164/antibiotics.42.1043

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Abstract

Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH₃CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C₂₂H₃₁NO₅. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.

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