SF2446, NEW BENZO[α]NAPHTHACENE QUINONE ANTIBIOTICS I. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF ANTIBIOTICS

UETO TAKEDA; TADAAKI OKADA; MASAYUKI TAKAGI; SHUICHI GOMI; JIRO ITOH; MASAJI SEZAKI; MITSUGU ITO; SHINJI MIYADOH; TAKASHI SHOMURA

doi:10.7164/antibiotics.41.417

SF2446, NEW BENZO[α]NAPHTHACENE QUINONE ANTIBIOTICS

I. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF ANTIBIOTICS

UETO TAKEDA, TADAAKI OKADA, MASAYUKI TAKAGI, SHUICHI GOMI, JIRO ITOH, MASAJI SEZAKI, MITSUGU ITO, SHINJI MIYADOH, TAKASHI SHOMURA

Author information

UETO TAKEDA
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
TADAAKI OKADA
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
MASAYUKI TAKAGI
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
SHUICHI GOMI
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
JIRO ITOH
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
MASAJI SEZAKI
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
MITSUGU ITO
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
SHINJI MIYADOH
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.
TAKASHI SHOMURA
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd.

JOURNAL FREE ACCESS

1988 Volume 41 Issue 4 Pages 417-424

DOI https://doi.org/10.7164/antibiotics.41.417

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Abstract

New antibiotics SF2446A1, A2, A3, B1 and B2 have been isolated from the culture of Streptomyces sp. SF2446 and antibiotic SF2446B3 has been obtained by methanolysis of SF2446B1 or B2. SF2446A1, A2 and B1 showed strong inhibitory activities against mycoplasmas and Gram-positive bacteria. Empirical molecular formulae of antibiotics SF2446-A1, A2, A3, B1, B2 and B3 were determined to be C₃₄H₃₅NO₁₅, C₃₄H₃₅NO₁₅, C₂₆H₂₁NO₁₁, C₃₄H₃₅NO₁₄, C₃₄H₃₅NO₁₄ and C₂₆H₂₁NO₁₀, respectively.

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