The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
O-DEMETHYLPAULOMYCINS A AND B, U-77, 802 AND U-77, 803, PAULOMENOLS A AND B, NEW METABOLITES PRODUCED BY STREPTOMYCES PAULUS
A. D. ARGOUDELISL. BACZYNSKYJS. A. MIZSAKF. B. SHILLIDAY
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1988 Volume 41 Issue 10 Pages 1316-1330

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Abstract

O-Demethylpaulomycin A (C33H44N2O17S), O-demethylpaulomycin B (C32H42N2O17S), paulomenol A (C29H43NO16), paulomenol B (C28H41NO16), and the hydrogen sulfide adducts of paulomycin A (U-77, 802, C34H48N2O17S2), and paulomycin B (U-77, 803, C33H46N2O17S2) have been isolated from fermentations of Streptomyces paulus strain 273. The structure of these compounds was determined by 1H and 13C NMR and fast atom bombardment mass spectrum spectroscopic techniques and degradative studies. The antibacterial properties of these new metabolites, which are related to paulomycins A and B (J. Antibiotics 35: 285-294, 1982), are briefly discussed.

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© Japan Antibiotics Research Association
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