ARUGOMYCIN, A NEW ANTHRACYCLINE ANTIBIOTIC III. BIOLOGICAL ACTIVITIES OF ARUGOMYCIN AND ITS ANALOGUES OBTAINED BY CHEMICAL DEGRADATION AND MODIFICATION

AKIHIRO SHIMOSAKA; HIROYUKI KAWAI; YOICHI HAYAKAWA; NOBUYASU KOMESHIMA; MASAYA NAKAGAWA; HARUO SETO; NOBORU OTAKE

doi:10.7164/antibiotics.40.1283

ARUGOMYCIN, A NEW ANTHRACYCLINE ANTIBIOTIC

III. BIOLOGICAL ACTIVITIES OF ARUGOMYCIN AND ITS ANALOGUES OBTAINED BY CHEMICAL DEGRADATION AND MODIFICATION

AKIHIRO SHIMOSAKA, HIROYUKI KAWAI, YOICHI HAYAKAWA, NOBUYASU KOMESHIMA, MASAYA NAKAGAWA, HARUO SETO, NOBORU OTAKE

Author information

JOURNAL FREE ACCESS

1987 Volume 40 Issue 9 Pages 1283-1291

DOI https://doi.org/10.7164/antibiotics.40.1283

Details

Abstract

Biological activities of arugomycin and its analogues obtained by chemical degradation and modification were evaluated. Differences in the sugar moieties affected their biological activities including induction of differentiation of mouse Friend erythroleukemia cells and mouse myeloid leukemia cells, antitumor activities against sarcoma S-180, Ehrlich ascites carcinoma and P388 leukemia, and cytotoxicity against murine leukemia cells. Some relationships were found between the sugar moieties and biological activities.

Corresponding author

Register with J-STAGE for free!