GLYCOCINNAMOYLSPERMIDINES, A NEW CLASS OF ANTIBIOTICS II. ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF LL-BM123β, γ<sub>1</sub>, AND γ<sub>2</sub>

J. H. MARTIN; M. P. KUNSTMANN; F. BARBATSCHI; M. HERTZ; G. A. ELLESTAD; M. DANN; G. S. REDIN; A. C. DORNBUSH; N. A. KUCK

doi:10.7164/antibiotics.31.398

GLYCOCINNAMOYLSPERMIDINES, A NEW CLASS OF ANTIBIOTICS

II. ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF LL-BM123β, γ₁, AND γ₂

J. H. MARTIN, M. P. KUNSTMANN, F. BARBATSCHI, M. HERTZ, G. A. ELLESTAD, M. DANN, G. S. REDIN, A. C. DORNBUSH, N. A. KUCK

Author information

J. H. MARTIN
Lederle Laboratories, A Division of American Cyanamid Company
M. P. KUNSTMANN
Lederle Laboratories, A Division of American Cyanamid Company
F. BARBATSCHI
Lederle Laboratories, A Division of American Cyanamid Company
M. HERTZ
Lederle Laboratories, A Division of American Cyanamid Company
G. A. ELLESTAD
Lederle Laboratories, A Division of American Cyanamid Company
M. DANN
Lederle Laboratories, A Division of American Cyanamid Company
G. S. REDIN
Lederle Laboratories, A Division of American Cyanamid Company
A. C. DORNBUSH
Lederle Laboratories, A Division of American Cyanamid Company
N. A. KUCK
Lederle Laboratories, A Division of American Cyanamid Company

JOURNAL FREE ACCESS

1978 Volume 31 Issue 5 Pages 398-404

DOI https://doi.org/10.7164/antibiotics.31.398

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Abstract

LL-BM123β, γ₁, andγ₂ are three new antibiotics produced by fermentation of an
unidentified species of Nocardia. These strongly basic, water-soluble compounds were isolated
from the culture filtrate by CM-Sephadex ion-exchange and carbon chromatography.
All three antibiotics are active against both gram-positive and gram-negative bacteria. A
mixture of LL-BM123γ₁ andγ₁ is more active than the β component but generally less
active than gentamicin.

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