ANTIMETABOLITES PRODUCED BY MICROORGANISMS. XI.1) 1-(S)-HYDROXY-2-(S, S)-VALYLAMIDO-CYCLOBUTANE-1-ACETIC ACID

DAVID L. PRUESS; JAMES P. SCANNELL; JOHN F. BLOUNT; HELEN A. AX; MARTHA KELLETTT; HOMAS H. WILLIAMS; ARTHUR STEMPEL

doi:10.7164/antibiotics.27.754

ANTIMETABOLITES PRODUCED BY MICROORGANISMS. XI.¹⁾

1-(S)-HYDROXY-2-(S, S)-VALYLAMIDO-CYCLOBUTANE-1-ACETIC ACID

DAVID L. PRUESS, JAMES P. SCANNELL, JOHN F. BLOUNT, HELEN A. AX, MARTHA KELLETTT, HOMAS H. WILLIAMS, ARTHUR STEMPEL

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JOURNAL FREE ACCESS

1974 Volume 27 Issue 10 Pages 754-759

DOI https://doi.org/10.7164/antibiotics.27.754

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Abstract

1-(S)-Hydroxy-2-(S, S)-valylamido-cyclobutane-l-acetic acid was isolated from a fermentation broth of an unidentified Streptomyces species X-1092. The structure was determined by single crystal X-ray diffraction analysis of the p-bromophenylcarbamyl derivative. The substance inhibits the growth of gram-positive microorganisms in a chemically defined medium but growth inhibition is partially reversed by L-cysteine.

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