Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE)-A Precursor of Oral Squamous Cell Carcinoma?
Abstract
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a
benign, chronic, reactive, self-healing lesion. It is composed of abundant
eosinophils and small lymphocytes. Several studies have shown varying observations on the relation of
tissue eosinophilia with the prognosis of oral cancer. Here, we present
a case of a 65-year-old male who presented with a non-healing ulcer on the
lateral border of tongue, which was suggestive of TUGSE on histopathological
examination. Patient was kept on strict monthly follow up and the second
re-biopsy was suggestive of moderately differentiated squamous cell carcinoma.
Literature does not support the transformation of TUGSE to oral squamous cell
carcinoma; however, our experience suggests a close vigilance of such lesions
due to its high clinical resemblance to malignancy. Hence, repeat biopsies on
regular basis is mandatory in cases where the clinical picture is highly
suspicious.
Keywords
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References
- 1. Medicum C. Ulcerative Granuloma With Stromal Case Report and Short Literature Review. POL J Pathol. 2011;172–5.
- 2. Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, et al. Traumatic ulcerative granuloma with stromal eosinophilia: A reactive lesion of the oral mucosa. Am J Clin Pathol. 2006;126(4):522–9.
- 3. Saravani S, Kadeh H, Derakhshanfar G. Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck. Dent Clin Exp J. 2016;In Press(In Press):90–4.
- 4. Bankur R, Rodrigues C, Anjaly D, Gopinathan P, Bankur P. Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma. Indian J Dent Res. 2016;27(5):463.
- 5. Jain M, Kasetty S, Khan S, Jain NK. Tissue eosinophilia in head and neck squamous neoplasia: An update. Exp Oncol. 2014;36(3):157–61.
- 6. Yellapurkar S, Natarajan S, Boaz K, Baliga M, Shetty P, Manaktala N, et al. Tumour-associated tissue eosinophilia in oral squamous cell carcinoma- A boon or a bane? J Clin Diagnostic Res. 2016;10(4):ZC65–8.
- 7. Falconieri G, Luna MA, Pizzolitto S, DeMaglio G, Angione V, Rocco M. Eosinophil-rich squamous carcinoma of the oral cavity: a study of 13 cases and delineation of a possible new microscopic entity. Ann Diagn Pathol. 2008;12(5):322–7.
- 8. Lowe D, Jorizzo J, Hutt MSR. Tumour-associated eosinophilia: A review. J Clin Pathol. 1981;34(12):1343–8.
- 9. Landman G, Lauris JRP, Kowalski LP, Latorre MRDO, Oliveira DT, Dorta RG. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. Histopathology. 2003;41(2):152–7.
- 10. Rakesh N, Devi Y, Majumdar K, Reddy SS, Agarwal K. Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. J Clin Exp Dent. 2015;7(1):e1–6.
Abstract
Project Number
Not applicable
References
- 1. Medicum C. Ulcerative Granuloma With Stromal Case Report and Short Literature Review. POL J Pathol. 2011;172–5.
- 2. Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, et al. Traumatic ulcerative granuloma with stromal eosinophilia: A reactive lesion of the oral mucosa. Am J Clin Pathol. 2006;126(4):522–9.
- 3. Saravani S, Kadeh H, Derakhshanfar G. Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck. Dent Clin Exp J. 2016;In Press(In Press):90–4.
- 4. Bankur R, Rodrigues C, Anjaly D, Gopinathan P, Bankur P. Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma. Indian J Dent Res. 2016;27(5):463.
- 5. Jain M, Kasetty S, Khan S, Jain NK. Tissue eosinophilia in head and neck squamous neoplasia: An update. Exp Oncol. 2014;36(3):157–61.
- 6. Yellapurkar S, Natarajan S, Boaz K, Baliga M, Shetty P, Manaktala N, et al. Tumour-associated tissue eosinophilia in oral squamous cell carcinoma- A boon or a bane? J Clin Diagnostic Res. 2016;10(4):ZC65–8.
- 7. Falconieri G, Luna MA, Pizzolitto S, DeMaglio G, Angione V, Rocco M. Eosinophil-rich squamous carcinoma of the oral cavity: a study of 13 cases and delineation of a possible new microscopic entity. Ann Diagn Pathol. 2008;12(5):322–7.
- 8. Lowe D, Jorizzo J, Hutt MSR. Tumour-associated eosinophilia: A review. J Clin Pathol. 1981;34(12):1343–8.
- 9. Landman G, Lauris JRP, Kowalski LP, Latorre MRDO, Oliveira DT, Dorta RG. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. Histopathology. 2003;41(2):152–7.
- 10. Rakesh N, Devi Y, Majumdar K, Reddy SS, Agarwal K. Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. J Clin Exp Dent. 2015;7(1):e1–6.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Project Number | Not applicable |
| Publication Date | March 18, 2020 |
| Submission Date | November 20, 2019 |
| Published in Issue | Year 2020Volume: 23 Issue: 1 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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