12915_2017_350_MOESM4_ESM.tif (566.89 kB)
Additional file 4: Figure S3. of Structural basis for potency differences between GDF8 and GDF11
figure
posted on 2017-03-03, 05:00 authored by Ryan Walker, Magdalena Czepnik, Erich Goebel, Jason McCoy, Ana Vujic, Miook Cho, Juhyun Oh, Senem Aykul, Kelly Walton, Gauthier Schang, Daniel Bernard, Andrew Hinck, Craig Harrison, Erik Martinez-Hackert, Amy Wagers, Richard Lee, Thomas ThompsonSequence alignment of human BMP2, GDF8, and GDF11. Gray bars above and below the sequence depict gross topology of the ligands. Residues that interact with the type I receptor (blue) and type II receptor (yellow) are shown on BMP2 based on the BMP2:ALK3:ActRIIA co-crystal structure (Protein Data Bank (PDB): 2GOO; [97]). The non-identical residues between GDF8 and GDF11 are highlighted in gray. (TIF 566Â kb)