Additional file 2: Figure S1. of Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses

Potential confounding characteristics of this study. Figure S2 RSV disease and viral load in healthy and RSV-infected individuals can be explained by nasopharyngeal microbial makeup (OTU-level). Figure S3 Species richness, but not diversity, is reduced in RSV-infected infants. Figure S4 Difference in Achromobacter, Veillonella, and Leptotrichia abundance between healthy and RSV-infected individuals with different disease severities. Figure S5 RSV-infected individuals with mild disease symptoms display an ‘intermediate’ nasopharyngeal microbiota compositional profile in comparison to moderate/severe disease and their recovery controls. Figure S6 Chemokine and cytokine levels during RSV infection and upon recovery. Figure S7 Comparison of OTUs from current study to Haemophilus reference species shows that Haemophilus-classified OTUs are predominantly belonging to Haemophilus influenzae species. (DOCX 968 kb)