Title

Molecular docking analysis of penta-galloyl-glucose with VEGF signaling molecules

Authors

Karthick Dharmalingam¹, Velvizhi Dharmalingam², Satheesh Durairaj³, Praveen Sharma¹ & Selvaraj Jayaraman^4,*

Affiliation

¹Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan - 342005, India; ²Department of Chemistry, Captain Srinivasa Murthy Central Ayurveda Research institute, CCRAS, Ministry of AYUSH, Government of India, Chennai – 600106; ³Department of chemistry, Siddha Central Research institute, Arumbakkam, Chennai – 600106; ⁴Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600 077, India; Corresponding author^*

Email

selvarajj.sdc@saveetha.com

Article Type

Research Article

Date

Received September 1, 2021; Revised October 18, 2021; Accepted October 18, 2021, Published November 30, 2021

It is of interest to document the molecular docking analysis data of penta-galloyl-glucose with VEGF signaling molecules in the context of cancer. Data shows that penta-galloyl-glucose have optimal binding affinities with VEGF-A,VEGFR-2, PKC, RAF, MEK, ERK and AKT with binding affinity of -7.9,-8.3,-8.6, -3.7,10.1,-9 and -10.8 kcal/mol respectively for further consideration in this context.

Keywords

Angiogenesis, VEGF signaling, penta galloyl glucose, molecular docking

Citation

Dharmalingam et al. Bioinformation 17(11): 924-927 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.