Title
Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS) domain from Actinobacterium dagang 5
Authors
Deepika Thandayuthapani*, Nivetha Chinnappa, Arjunan Annavi & Muthusevam Manickam*
Affiliation
Department of Biotechnology, Bharathidasan University, Tiruchirappalli-620020, Tamilnadu, India; *Corresponding author
M. Muthuselvam - E-mail: muthuphd@gmail.com; Deepika Thandayuthapani - E-mail: dpsmibio@gmail.com
Article Type
Research Article
Date
Received August 23, 2021; Revised September 20, 2021; Accepted September 20, 2021, Published September 30, 2021
Abstract
This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent Actinobacterium dagang 5 from Gulf of Manner, which shows broadspectrum activity against several pathogens. So the isolate was used for overall metabolic profiling studies on crude extract and phylogeny pattern analysis of NRPS A-domain, which is an important gene clusters and plays vital role in production of bioactive metabolites. The result suggests that Actinobacterium dagang 5 has the potential to produce a new type of antibacterial compounds.
Keywords
Actinobacterium dagang 5, NRPS, Adenylation domain, Metabolite profiling, Gas chromotography.
Citation
Thandayuthapani et al. Bioinformation 17(9): 809-813 (2021)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
