CC BY-NC 4.0 · Arch Plast Surg 2021; 48(05): 559-567
DOI: 10.5999/aps.2021.00339
Research/Experimental
Review Article

Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration

Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA
Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA
,
Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA
,
Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA
,
Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA
,
Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA
,
Ricardo A. Torres
Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA
,
Gunel Guliyeva
Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA
,
Thiha Aung
Center of Plastic, Aesthetic, Hand, and Reconstructive Surgery, University of Regensburg, Regensburg, Germany
,
Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA
› Author Affiliations
This study was supported in part by the Mayo Clinic Center for Individualized Medicine, Mayo Clinic Center for Regenerative Medicine and the Plastic Surgery Foundation.

The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study’s goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature on the use of ADSCs in lymphatic tissue engineering and regeneration. There were no language or time frame limitations, and the following search strategy was applied: ((Adipose stem cell) OR Adipose-derived stem cell)) AND ((Lymphedema) OR Breast Cancer Lymphedema). Only original research manuscripts were included. Fourteen studies fulfilled the inclusion criteria. Eleven studies were experimental (in vitro or in vivo in animals), and only three were clinical. Publications on the topic demonstrated that ADSCs promote lymphangiogenesis, and its effect could be enhanced by modulation of vascular endothelial growth factor-C, interleukin-7, prospero homeobox protein 1, and transforming growth factor-β1. Pilot clinical studies included 11 patients with breast cancer-related lymphedema, and no significant side effects were present at 12-month follow-up. Literature on the use of ADSCs in lymphatic tissue engineering and regeneration demonstrated promising data. Clinical evidence is still in its infancy, but the scientific community agrees that ADSCs can be useful in regenerative lymphangiogenesis. Data collected in this review indicate that unprecedented advances in lymphedema treatment can be anticipated in the upcoming years.



Publication History

Received: 07 February 2021

Accepted: 16 June 2021

Article published online:
19 March 2022

© 2021. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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