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Praxis medica
2016, vol. 45, br. 3-4, str. 15-21
Ispitivanje aktivnosti mijeloperoksidaze, kao pokazatelja inflamacije, kod gojaznih i ispitanika sa metaboličkim sindromom
Matić Tamaraa, Puhalo Sladoje Draganab, Kisić Bojanaa ORCID, Trajković Goranc, Dragojević Ilijaa ORCID, Mirić Dijanaa ORCID
aUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Medicinski fakultet, Institut ta biohemiju, Srbija
bUniverzitet u Istočnom Sarajevu, Medicinski fakultet, Foča, Republika Srpska, BiH
cUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku, Srbija

e-adresa: tamaramatic87@yahoo.com
Sažetak
Gojaznost humanog organizma je složen metabolički poremećaj koji predstavlja jedan od najčešćih savremenih zdravstvenih problema. Brojna istraživanja ukazuju na udruženost hronične inflamacije niskog stepena i gojaznosti. Mijeloperoksidaza (MPO) i njeni reaktivni oksidanti učestvuju u oštećenju tkiva tokom inflamatornih procesa u humanom organizmu. Cilj istraživanja bilo je ispitivanje aktivnosti enzima mijeloperoksidaze u serumu gojaznih i ispitanika sa metaboličkim sindromom i testiranje povezanosti aktivnosti MPO i drugih pokazatelja zapaljenja u krvi ispitanika. Ispitanici su na osnovu antropometrijskih parametara i biohemijskih pokazatelja podeljeni u tri grupe: normalno uhranjeni (n=30), ispitanici sa abdominalnom gojaznošću (n=30) i ispitanici sa metaboličkim sindromom (n=30). U serumu ispitanika određivana je hlorinišuća aktivnost MPO spektrofotometrijski. Tokom ispitivanja utvrđene su značajne razlike u aktivnosti MPO kod sve tri grupe ispitanika i to najveća aktivnost izmerena je kod ispitanika sa metaboli čkim sindromom (p<0.001). Utvrđena je pozitivna korelacija između aktivnost MPO i aterogenog indeksa, kao i između MPO i koncentracije LDL-holesterola, dok je negativna povezanost utvrđena između MPO i koncentracije HDL-holesterola. Ispitivanje je pokazalo da aktivnost MPO progresivno raste sa gojaznošću i metaboličkim sindromom. Dobijeni rezultati ukazju da MPO može biti od zna čaja u patofiziološkim mehanizmima koji dovode do razvoja komplikacija kod gojaznosti i metaboličkog sindroma.
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O članku

jezik rada: srpski
vrsta rada: originalan članak
DOI: 10.5937/pramed1604015M
objavljen u SCIndeksu: 12.06.2017.
Creative Commons License 4.0

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