METABOLIC ACTIVITIES OF VITAMIN D IN ANIMALS VI. PHYSIOLOGICAL ACTIVITIES OF VITAMIN D SULFATE

YOSHIKAZU SAHASHI; TAKAO SUZUKI; MIYATO HIGAKI; MASAYUKI TAKAHASHI; TSUTOMU ASANO; TADAO HASEGAWA; EIKO MIYAZAWA

doi:10.5925/jnsv1954.13.37

METABOLIC ACTIVITIES OF VITAMIN D IN ANIMALS

VI. PHYSIOLOGICAL ACTIVITIES OF VITAMIN D SULFATE

YOSHIKAZU SAHASHI, TAKAO SUZUKI, MIYATO HIGAKI, MASAYUKI TAKAHASHI, TSUTOMU ASANO, TADAO HASEGAWA, EIKO MIYAZAWA

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JOURNAL FREE ACCESS

1967 Volume 13 Issue 1 Pages 37-40

DOI https://doi.org/10.5925/jnsv1954.13.37

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Abstract

1. Toxicity of vitamin D₂ sulfate in saline solution in mice was tested by intraperitoneal injection. The lethal dose, LD₅₀, in mice, weighing about 20g, was about 2, 5000, 000I.U./kg.
2. Antirachitic potency of vitamin D₂ sulfate was tested by prophylactic method and it was found that the compound had about the same effect as vitamin D₂.
3. By administering 5, 000I.U. of the compound or 10I.U. of vitamin D₂ per head per os daily, gained the body weight till 15 days, whereas those receiving 5, 000I.U. of vitamin D₂ per head per os daily resulted in the failure to gain weight after 10 days.

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