Communications
Cathodic N–O Bond Cleavage of N-Alkoxy Amide
2023 Volume 91 Issue 11 Pages 112005
Details
2023 Volume 91 Issue 11 Pages 112005
Cathodic reduction efficiently cleaved N–O bonds. The simple cathodic reduction of Weinreb amides in a divided cell afforded the corresponding amide in good yields. Cyclic voltammetry experiments and density functional theory calculations suggested that the direct reduction of the N-methoxy amide generates the methoxy radical and amide anion. The release of methanol derived from methoxy radical would be the driving force of the N–O bond cleavage.
