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open access

Vol 53, No 2 (2019)
Research Paper
Submitted: 2018-11-19
Accepted: 2018-11-19
Published online: 2019-02-26
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Health-related quality of life and medication adherence in elderly patients with epilepsy

Soudabeh Hamedi-Shahraki1, Mohammad-Reza Eshraghian1, Mir-Saeed Yekaninejad1, Mehdi Nikoobakht2, Aliakbar Rasekhi3, Hui Chen4, Amir Pakpour56
DOI: 10.5603/PJNNS.a2019.0008
·
Pubmed: 30807640
·
Neurol Neurochir Pol 2019;53(2):123-130.
Affiliations
  1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran
  2. Department of Neurosurgery, Iran University of Medical Sciences, Tehran
  3. Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran, Islamic Republic Of
  4. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia
  5. Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  6. Department of Nursing, School of Health and Welfare, Jönköping University, Jönköping, Sweden

open access

Vol 53, No 2 (2019)
Research papers
Submitted: 2018-11-19
Accepted: 2018-11-19
Published online: 2019-02-26

Abstract

Objective. Considering the high prevalence of epilepsy in the elderly and the importance of maximising their quality of life (QoL), this study aimed to investigate the relationship between medication adherence and QoL, and the mediating effects of medication adherence on the association between serum antiepileptic drug (AED) level and seizure severity with QoL in elderly epileptics.

Methods. In a longitudinal study, 766 elderly patients with epilepsy who were prescribed a minimum of one antiepileptic drug were selected by convenience sampling method. A Medication Adherence Report Scale (MARS-5) questionnaire was completed at the baseline. Seizure severity and QoL were assessed after six months using the Liverpool Seizure Severity Scale (LSSS) and the QoL in Epilepsy (QOLIE-31) questionnaires respectively. Serum level of AED was also measured at six-month follow-up.

Results. Medication adherence was significantly correlated with both seizure severity (β = –0.33, p < 0.0001) and serum AED level (β = 0.29, p < 0.0001) after adjusting for demographic and clinical characteristics. Neither QoL nor its sub-classes were correlated with seizure severity. In addition, a significant correlation was not observed between serum AED level and QoL. However, medication adherence was significantly correlated with QoL (β = 0.30, p < 0.0001). The mediating effects of medication adherence on the association between serum AED level (Z = 3.39, p < 0.001) and seizure severity (Z = –3.47, p < 0.001) with QoL were supported by the Sobel test.

Conclusion. This study demonstrates that medication adherence has a beneficial impact on QoL in elderly epileptics. Therefore, adherence to treatment should be monitored to improve their QoL.

Abstract

Objective. Considering the high prevalence of epilepsy in the elderly and the importance of maximising their quality of life (QoL), this study aimed to investigate the relationship between medication adherence and QoL, and the mediating effects of medication adherence on the association between serum antiepileptic drug (AED) level and seizure severity with QoL in elderly epileptics.

Methods. In a longitudinal study, 766 elderly patients with epilepsy who were prescribed a minimum of one antiepileptic drug were selected by convenience sampling method. A Medication Adherence Report Scale (MARS-5) questionnaire was completed at the baseline. Seizure severity and QoL were assessed after six months using the Liverpool Seizure Severity Scale (LSSS) and the QoL in Epilepsy (QOLIE-31) questionnaires respectively. Serum level of AED was also measured at six-month follow-up.

Results. Medication adherence was significantly correlated with both seizure severity (β = –0.33, p < 0.0001) and serum AED level (β = 0.29, p < 0.0001) after adjusting for demographic and clinical characteristics. Neither QoL nor its sub-classes were correlated with seizure severity. In addition, a significant correlation was not observed between serum AED level and QoL. However, medication adherence was significantly correlated with QoL (β = 0.30, p < 0.0001). The mediating effects of medication adherence on the association between serum AED level (Z = 3.39, p < 0.001) and seizure severity (Z = –3.47, p < 0.001) with QoL were supported by the Sobel test.

Conclusion. This study demonstrates that medication adherence has a beneficial impact on QoL in elderly epileptics. Therefore, adherence to treatment should be monitored to improve their QoL.

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Keywords

epilepsy, medication adherence, seizure, quality of life, elderly

About this article
Title

Health-related quality of life and medication adherence in elderly patients with epilepsy

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 2 (2019)

Article type

Research Paper

Pages

123-130

Published online

2019-02-26

Page views

2803

Article views/downloads

2004

DOI

10.5603/PJNNS.a2019.0008

Pubmed

30807640

Bibliographic record

Neurol Neurochir Pol 2019;53(2):123-130.

Keywords

epilepsy
medication adherence
seizure
quality of life
elderly

Authors

Soudabeh Hamedi-Shahraki
Mohammad-Reza Eshraghian
Mir-Saeed Yekaninejad
Mehdi Nikoobakht
Aliakbar Rasekhi
Hui Chen
Amir Pakpour

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