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Vol 93, No 11 (2022)
Research paper
Published online: 2022-06-03
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Genetic variants of progesterone receptor in etiology of preterm delivery

Dorota G. Boron1, Grazyna Kurzawinska12, Agata Szpera-Gozdziewicz1, Krzysztof Drews1, Zbyszko Malewski1, Martyna Kozlowska-Wytyk3, Adam Kaminski4, Tadeusz Sulikowski5, Agnieszka Seremak-Mrozikiewicz12
DOI: 10.5603/GP.a2022.0032
·
Pubmed: 35894492
·
Ginekol Pol 2022;93(11):930-936.
Affiliations
  1. Division of Perinatology and Women’s Diseases, Poznan University of Medical Sciences, Poznan, Poland
  2. Laboratory of Molecular Biology in Division of Perinatology and Women’s Diseases, Poznan University of Medical Sciences, Poznan, Poland
  3. Division of Obstetrics and Gynecology, Holy Family Hospital, Poznan, Poland
  4. Department of Pediatric Orthopedics and Traumatology, Pomeranian Medical University, Szczecin, Poland
  5. General, Mini-Invasive and Gastroenterological Surgery Clinic, Pomeranian Medical University, Szczecin, Poland

open access

Vol 93, No 11 (2022)
ORIGINAL PAPERS Obstetrics
Published online: 2022-06-03

Abstract

Objectives: Preterm delivery (PTD) accounts for around 11% of pregnancies worldwide. Unfortunately, no diagnostic
indicator, specific mechanism or genetic predisposition has yet been identified. One of the hypotheses suggest local or
functional progesterone decrease as a potential reason for preterm uterine contractions leading to preterm delivery. It is
believed that any change in progesterone receptor DNA may be crucial for higher risk of preterm delivery due to abnormal response to prostaglandins, normally inhibited by properly built progesterone. The aim of this study was to determine whether there is an association between progesterone gene polymorphisms (PROGINS and +331G/A) and preterm birth.

Material and methods: A total of 230 women were enrolled, including 115 cases of preterm deliveries (between 22
and 36 weeks of gestation) and 115 healthy mothers of full-term infants. Genomic DNA was isolated from the blood
sample. Polymerase chain reaction (PCR) amplification was carried out in a final volume of 25 μL. Genotyping was assayed by PCR. Statistical analysis of the results was conducted with p < 0.05 accepted as statistically significant.

Results: For both PROGINS (Alu ins/del) and +331G/A (rs10895068) polymorphisms were equally frequent in case
and control group. The prevalence of PGR alleles in both groups was also comparable.

Conclusions: The results of our study showed no association between progesterone gene polymorphisms (PROGINS
and +331G/A) and risk of preterm delivery. Identifying mechanisms to prolong the length of gestation, particularly in
women at risk for preterm delivery, will improve both maternal and fetal outcomes.

Abstract

Objectives: Preterm delivery (PTD) accounts for around 11% of pregnancies worldwide. Unfortunately, no diagnostic
indicator, specific mechanism or genetic predisposition has yet been identified. One of the hypotheses suggest local or
functional progesterone decrease as a potential reason for preterm uterine contractions leading to preterm delivery. It is
believed that any change in progesterone receptor DNA may be crucial for higher risk of preterm delivery due to abnormal response to prostaglandins, normally inhibited by properly built progesterone. The aim of this study was to determine whether there is an association between progesterone gene polymorphisms (PROGINS and +331G/A) and preterm birth.

Material and methods: A total of 230 women were enrolled, including 115 cases of preterm deliveries (between 22
and 36 weeks of gestation) and 115 healthy mothers of full-term infants. Genomic DNA was isolated from the blood
sample. Polymerase chain reaction (PCR) amplification was carried out in a final volume of 25 μL. Genotyping was assayed by PCR. Statistical analysis of the results was conducted with p < 0.05 accepted as statistically significant.

Results: For both PROGINS (Alu ins/del) and +331G/A (rs10895068) polymorphisms were equally frequent in case
and control group. The prevalence of PGR alleles in both groups was also comparable.

Conclusions: The results of our study showed no association between progesterone gene polymorphisms (PROGINS
and +331G/A) and risk of preterm delivery. Identifying mechanisms to prolong the length of gestation, particularly in
women at risk for preterm delivery, will improve both maternal and fetal outcomes.

Full Text:

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Keywords

genetic polymorphism; preterm delivery; progesterone receptor gene

About this article
Title

Genetic variants of progesterone receptor in etiology of preterm delivery

Journal

Ginekologia Polska

Issue

Vol 93, No 11 (2022)

Article type

Research paper

Pages

930-936

Published online

2022-06-03

Page views

3905

Article views/downloads

352

DOI

10.5603/GP.a2022.0032

Pubmed

35894492

Bibliographic record

Ginekol Pol 2022;93(11):930-936.

Keywords

genetic polymorphism
preterm delivery
progesterone receptor gene

Authors

Dorota G. Boron
Grazyna Kurzawinska
Agata Szpera-Gozdziewicz
Krzysztof Drews
Zbyszko Malewski
Martyna Kozlowska-Wytyk
Adam Kaminski
Tadeusz Sulikowski
Agnieszka Seremak-Mrozikiewicz

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