Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China

Shibo Li; Chuan Xue; Yongfeng Fu; Jiali Wang; Xianjun Ding; Ruiding Liu; Zhiyi Lin; Nengming Chai; Xuchun Yang; Yekai Wang; Yuncheng Li; Zheen Zhang; Xunjia Cheng; Wenhong Zhang

doi:10.5582/bst.2011.v5.6.273

Case Report

Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China

Shibo Li, Chuan Xue, Yongfeng Fu, Jiali Wang, Xianjun Ding, Ruiding Liu, Zhiyi Lin, Nengming Chai, Xuchun Yang, Yekai Wang, Yuncheng Li, Zheen Zhang, Xunjia Cheng, Wenhong Zhang

Author information

Shibo Li
Department of Infectious Diseases, Zhoushan Hospital
Chuan Xue
Graduate College of Jiamusi University
Yongfeng Fu
Department of Microbiology and Parasitology, Shanghai Medical College of Fudan University
Jiali Wang
Department of Infectious Diseases, Huashan Hospital, Fudan University
Xianjun Ding
Department of Infectious Diseases, Zhoushan Hospital
Ruiding Liu
Department of Gastroenterology, Daishan People's Hospital
Zhiyi Lin
Department of Infectious Diseases, Zhoushan Hospital
Nengming Chai
Department of Microbiology and Parasitology, Shanghai Medical College of Fudan University
Xuchun Yang
Department of Infectious Diseases, Zhoushan Hospital
Yekai Wang
Department of Infectious Diseases, Zhoushan Hospital
Yuncheng Li
Department of Infectious Diseases, Zhoushan Hospital
Zheen Zhang
Department of Infectious Diseases, Zhoushan Hospital
Xunjia Cheng
Department of Microbiology and Parasitology, Shanghai Medical College of Fudan University
Wenhong Zhang
Department of Infectious Diseases, Huashan Hospital, Fudan University

Keywords: Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV), molecular diagnosis, sporadic infection

JOURNAL FREE ACCESS

2011 Volume 5 Issue 6 Pages 273-276

DOI https://doi.org/10.5582/bst.2011.v5.6.273

Details

Abstract

We report here a clinical and molecular study on a case suffer from severe fever with thrombocytopenia syndrome (SFTS) due to a new type of bunyavirus, named SFTS bunyavirus (SFTSV), in Zhejiang Province China. The key clinical features of this patient include fever, lymphocytopenia and thrombocytopenia. We carried out a serological and molecular investigation in the indicated case and on relatives with close contact. The SFTSV infection was confirmed through amplification of viral genetic material using the polymerase chain reaction (PCR) from the patient's serum, but not relatives with close contact. Subsequently direct sequence of PCR product demonstrated a homology of 94-96% in the nucleotide sequence compared to a reference sequence previously reported, in which the majority of patients originated from an epidemic area of Central and Northeast China. Our results suggest that SFTSV can occur in a non-epidemic area due to a similar strain of SFTSV that apparently affect the blood system, implying the importance of dissecting the pathogenesis of SFTS as well as mode of infection.

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