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Current trends and new methods of detection of SARS-CoV-2 infection

Document Type : Review Article

Authors

1 Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

2 Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran

3 Biotechnology and Biological Science Research Center, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

SARS-CoV- 2 is the causative agent of the global pandemic, also known as Covid-19. This virus belongs to a group of coronaviruses and has affected more than ten million people across the globe, causing nearly half a million deaths worldwide. The pandemic has spread worldwide, originating in the Wuhan Hubei province of China in 2019. The disease is a significant challenge as there is no antiviral treatment. This review will address current trends and emerging new methods for detecting SARS-CoV-2 in the laboratoryat present. Reverse transcriptase PCR or RT-PCR is the gold standard for detecting SARS-CoV-2 disease. The seroprevalence of Covid-19 is performed using antibody detection tests using ELISA and antigen detection as rapid tests. In clinical practice, preliminary disease identification is made based on Chest radiographs, computed tomography, and positron emission tomography (PET) scans. As the pandemic has progressed, newer methods of detection like CRISPR, nanotechnology-enabled solutions, and biosensors have emerged as new methods of detecting SARS-CoV-2.  

Graphical Abstract

Current trends and new methods of detection of SARS-CoV-2 infection

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ِDr. Mohammad Reza Mohammadi
Tarbiat Modares University

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Cellular, Molecular and Biomedical Reports
Volume 2, Issue 3
Cellular, Molecular and Biomedical Reports (Online ISSN: 2823-2550)
September 2022
Pages 138-150
Files
History
  • Receive Date: 03 March 2022
  • Revise Date: 11 April 2022
  • Accept Date: 21 May 2022
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