Methyl glycyrrhetinate was esterified at position C3 of ring A using different amino acids. A short, unbranched chain of four carbon atoms with two amino groups in positions 2 and 4 was shown to be the most active compound of this series (IC50 = 0:8 M on liposarcoma Lipo cells). These compounds trigger apoptosis as shown by an acridine orange/ethidium bromide assay, trypan blue tests and DNA laddering experiments.
Graphical Abstract
Synthesis and Cytotoxic Activity of Methyl Glycyrrhetinate Esterified with Amino Acids
Received: 2012-4-19
Published Online: 2014-6-2
Published in Print: 2012-7-1
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