Reviews
The pathogenic role of metabolism in Sjögren’s syndrome
S. Colafrancesco1, E. Simoncelli2, R. Priori3, M. Bombardieri4
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, and Rheumatology and Clinical Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS Humanitas Research Hospital, Rozzano, Italy. serena.colafrancesco18@gmail.com
- Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Universita’ di Roma Sapienza, Roma, Italy.
- Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Universita’ di Roma Sapienza, and Saint Camillus International University of Health Science, UniCamillus, Rome, Italy.
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK.
CER17334
2023 Vol.41, N°12
PI 2538, PF 2546
Reviews
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PMID: 38149514 [PubMed]
Received: 28/11/2023
Accepted : 04/12/2023
In Press: 23/12/2023
Published: 23/12/2023
Abstract
The link between immune cell function and cell metabolic reprogramming is currently known under the term “immunometabolism”. Similarly to the Warburg’s effect described in cancer cells, in activated immune cells an up-regulation of specific metabolic pathways has been described and seems to be pathogenic in different inflammatory conditions. Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that affects the exocrine glands and is characterised by a progressive loss of secretory function. Despite the increasing amount of evidence on the ability of metabolism in regulating cell behaviour in inflammatory or tumoral conditions, the field of metabolism in SS is still for the most part unexplored. The aim of this review is to summarise currently available studies evaluating cell metabolism in SS with a particular focus on the possible pathogenic role of metabolic changes in immune and non-immune cells in this condition.
